Vanesa Lafarga

This study shows that ARC acts as a retroviral-like capsid for TDP-43 spreading in ALS and FTD, and that Lenacapavir blocks this process.

This study identifies the accumulation of orphan ribosomal proteins as a molecular hallmark of ALS, linking it to various ALS-related mutations and neurotoxins.

The paper identifies a chemical inducer of ribophagy, SALSa, that reduces toxicity of ALS-related arginine-rich peptides and extends lifespan in a Drosophila model.

This study identifies GRK2's role in regulating AKT activation during the G2/M transition, showing its dependence on p53 for checkpoint control and tumor cell survival.

This study shows that arginine-rich peptides cause nucleolar stress, leading to ribosomopathy and accelerated ageing in mice, with mTOR inhibition alleviating lifespan reduction.

This study identifies Hnrnpk as a master regulator of nucleolar stress and ribosome impairment, linking nucleolar abnormalities to aging and bone marrow failure.

This study identifies SPHK inhibitors as a new class of translation suppressors independent of mTOR, linking lipid metabolism to mRNA translation.

This study shows arginine-rich CPPs like (PR)n displace DNA- and RNA-binding factors, impairing nucleic acid processes and causing toxicity, similar to PROTAMINE's effects.