AZD5582 robustly reactivates latently infected cells and clears the majority of those reactivated from the SIV reservoir
Tin Phan, Maud Mavigner, Amir Dashti, Ann Chahroudi, Ruy Miguel Ribeiro, Ruian Ke, Alan S. Perelson
This study quantifies AZD5582's effect on SIV reservoirs in macaques, showing it reactivates 25% of latent cells per dose and clears 60-79% of reactivated cells.
bioRxiv · Jun 2, 2026 · PreprintMicrobiology