Anticipating on-target resistance to WRN inhibitors in microsatellite unstable cancers
Mark E. Orcholski, Nancy Laterreur, Wardah Masud, Shamika Shenoy, Vincent Chapdelaine, Julian Bowlan, Amisha Minju-OP, Júlia-Jié Cabré-Romans, Tanja Sack, Chris Fiore, Jordan T.F. Young, Alejandro Álvarez-Quilón, Raquel Cuella-Martin
This study identifies on-target resistance mechanisms to WRN inhibitors in MSI cancers using functional genomics and shows how to improve therapeutic durability through drug selection and combination strategies.
bioRxiv · Jan 24, 2026 · PreprintCancer Biology