TLR7 inhibition limits cardiac ischemic injury by disrupting ITGAM-dependent immune-endothelial interaction
Yijia Li, Yang Yang, Chanhee Park, Boyang Ren, Ruoxing Li, Amol Shetty, Brittney Williams, Ziyi Li, Lin Zou, Wei Chao
This study identifies TLR7 as a mediator of post-ischemic inflammation and shows that its inhibition reduces myocardial injury by disrupting ITGAM-dependent immune-endothelial interactions.
JACC Basic to Translational Science · Jul 14, 2026Peer-reviewedImmunology