Osmotic pressure induces unexpected relaxation of contractile 3D microtissue
Giovanni Cappello, Fanny Wodrascka, Genesis Marquez-Vivas, Amr Eid Radwan, Parvathy Anoop, Pietro Mascheroni, Jonathan Fouchard, Ben Fabry, Davide Ambrosi, Pierre Recho, Simon de Beco, Martial Balland, Thomas Boudou
This study shows that osmotic compression relaxes tissue contractility in different cell types, mediated by RhoA and myosin activity, suggesting a feedback mechanism in morphogenesis.
The European Physical Journal E · Jun 24, 2025Peer-reviewedBiophysics