Zinc transporter somatic gene mutations cause primary aldosteronism
Juilee Rege, Kazutaka Nanba, Sascha Bandulik, Carla Kosmann, Amy Blinder, Pankaj Vats, Chandan Kumar‐Sinha, Antônio Marcondes Lerário, Tobias Else, Yuto Yamazaki, Fumitoshi Satoh, Hironobu Sasano, Thomas J. Giordano, Tracy Ann Williams, Martín Reincke, , William E. Rainey
The paper identifies recurrent SLC30A1 mutations in aldosterone-producing adenomas and shows they cause abnormal ion transport leading to aldosterone excess in primary aldosteronism.
bioRxiv · Jul 25, 2022 · PreprintGenetics