William E. Rainey

This study identifies somatic MCOLN3 mutations in aldosterone-producing adenomas that disrupt calcium regulation and lead to increased aldosterone production in primary aldosteronism.

This study identifies WNT2B as a key regulator of adrenal aldosterone production, showing its role in zG function and linking its variants to primary aldosteronism and a new form of familial hypoaldosteronism.

The paper identifies recurrent SLC30A1 mutations in aldosterone-producing adenomas and shows they cause abnormal ion transport leading to aldosterone excess in primary aldosteronism.

The paper identifies RNA-binding proteins and RNA decay factors that regulate aldosterone production kinetics in steroidogenic cells through coordinated transcription and decay mechanisms.