Aaron M. Udager

scRNA-seq and genomics analyses reveal key mechanisms of inverted papilloma-associated sinonasal squamous cell carcinoma malignant transformation

This study identifies molecular and immune mechanisms driving malignant transformation from inverted papilloma to sinonasal squamous cell carcinoma using multi-omics analyses.

Multi-resolution Spatial Graphical Regression Models for Hierarchical Spatial Transcriptomics Data

This paper introduces a Bayesian multi-resolution spatial graphical regression framework to infer spatially varying gene networks from hierarchical spatial transcriptomics data, showing improved network recovery and identifying key regulatory hubs in kidney cancer.

Enhancing precision medicine for patients with breast cancer brain metastases through functional drug testing

This study uses patient-derived organoids to test drug responses in breast cancer brain metastases, showing subtype-specific variations and the potential of PI3K inhibitors regardless of PIK3CA mutation status.

Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma

The paper identifies a transcriptional transition state in ccRCC cells that drives sarcomatoid transformation and enhances immunotherapy response via macrophage and T-cell interactions.

Somatic Mutations in MCOLN3 in Aldosterone-Producing Adenomas cause Primary Aldosteronism.

This study identifies somatic MCOLN3 mutations in aldosterone-producing adenomas that disrupt calcium regulation and lead to increased aldosterone production in primary aldosteronism.

Zinc transporter somatic gene mutations cause primary aldosteronism

The paper identifies recurrent SLC30A1 mutations in aldosterone-producing adenomas and shows they cause abnormal ion transport leading to aldosterone excess in primary aldosteronism.