An orally available PfPKG inhibitor blocks sporozoite infection of the liver
Hanna Dhiyebi, Aminata Mbaye, Anusha Thaniana, John Gilleran, Tyler Eck, Kutub Ashraf, Karl Kudyba, Howard Shihao Fan, Steve A. Seibold, K.P. Battaile, John J. Siekierka, William Evan Johnson, Alison Roth, Amy De Rocher, S. Lovell, , Purnima Bhanot
This paper describes RUPB-61, an orally available PfPKG inhibitor that prevents liver infection by malaria sporozoites and shows activity against drug-resistant isolates.
bioRxiv · Jul 9, 2025 · PreprintMicrobiology