Activating Ras-MAPK pathway variants drive hippocampal clonal competition in human epilepsy
Sattar Khoshkhoo, Mingyun Bae, Yilan Wang, Ashton Tillett, Rosita B. Ramirez, Benjamin Finander, Emily D. Egan, L. Marx, Dipan Patel, Zinan Zhou, Yasmine Chahine, Brian H. Chhouk, Sofía Zoullas, Abbe Lai, Roland Coras, , Christopher A. Walsh
This study identifies somatic Ras-MAPK pathway variants in hippocampal tissue from patients with drug-resistant epilepsy, showing their association with clonal competition and worse surgical outcomes.
bioRxiv · Jan 27, 2026 · PreprintGenetics