Disruption of IRE1α through its Kinase Domain Attenuates Multiple Myeloma
Jonathan M Harnoss, Adrien Le Thomas, Scot A Marsters, David A Lawrence, Min Lu, Yung-Chia Ariel Chen, Jing Qing, Klara Totpal, David Kan, Ehud Segal, Heidi Ackerly Wallweber, Weiru Wang, Kevin Clark, Susan Kaufman, Maureen Beresini, , Avi Ashkenazi
This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.
bioRxiv · Dec 14, 2018 · PreprintCancer Biology