Regulated control of gene therapies with a drug induced switch
Alex Mas Monteys, Amiel A. Hundley, Paul T. Ranum, Euyn Lim, Luis Tecedor, Amy Muehlmatt, Beverly L. Davidson
This paper introduces a drug-inducible switch system (Xon) for precise control of gene therapies, enabling gene silencing or replacement with oral small molecule inducers that are safe and bioavailable.
bioRxiv · Feb 21, 2020 · PreprintMolecular Biology