Author

Alex Mas Monteys

Children's Hospital of PhiladelphiaORCID 0000-0003-2539-8468Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Beverly L. DavidsoniD· 3 shared Abigail I DichteriD· 1 shared Aeverie E. R. HeuchaniD· 1 shared Aleksandar IzdaiD· 1 shared Alicia R. SmithiD· 1 shared Alvaro MurilloiD· 1 shared Alys N AstoniD· 1 shared Alysha S TayloriD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Beverly L. DavidsonORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintFeb 19, 2024

Cas9 Nickase-Mediated Contraction of CAG/CTG Repeats in Vivo is Accompanied by Improvements in Huntington's Disease Pathology

Alvaro Murillo, Melanie Alpaugh, Ruban Rex Peter Durairaj…·Vincent Dion

The paper demonstrates that CRISPR-Cas9 nickase can contract CAG/CTG repeats in patient-derived cells and improve molecular and behavioral phenotypes in Huntington's disease.

8 citations

humanmouse

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NeurosciencebioRxivPreprintJan 31, 2024

AAV-based delivery of RNAi targeting Ataxin-2 improves survival, strength, and pathology in mouse models of rapidly and slowly progressive sporadic ALS

Defne A. Amado, Ashley B. Robbins, Alicia R. Smith…·Beverly L. Davidson

7 citations

mousebulk RNA-seq

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Molecular BiologybioRxivPreprintFeb 21, 2020

Regulated control of gene therapies with a drug induced switch

Alex Mas Monteys, Amiel A. Hundley, Paul T. Ranum…·Beverly L. Davidson

This paper introduces a drug-inducible switch system (Xon) for precise control of gene therapies, enabling gene silencing or replacement with oral small molecule inducers that are safe and bioavailable.

DOI 10.1101/2020.02.21.956664

humanexperimental assay

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