Rescuing functional defects in a zebrafish model of CDKL5 deficiency disorder: Contribution to the identification of new therapeutic compounds
Tatiana Varela, Débora Varela, Joao MA Santos, Ana Hernandez, Max Domingues, Vanessa D. Pinto, Natércia Conceição, M. Leonor Cancela
This study identifies potential therapeutic compounds for CDKL5 deficiency disorder using a zebrafish model, finding that fisetin and others partially restore locomotor and craniofacial defects.
bioRxiv · Mar 16, 2026 · PreprintNeuroscience