A Dual Role for DGAT-mediated Lipid Droplet Biogenesis in Ferroptosis Regulation
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristýna Brejchová, Maria Fedorova, Ondřej Kuda, Toni Petan
This study shows that DGAT-mediated lipid droplet biogenesis regulates ferroptosis by modulating lipid distribution and membrane unsaturation, with context-dependent effects in different cancer cell types.
bioRxiv · May 21, 2025 · PreprintCell Biology