Critical role of Cas9 aggregation on in vitro DNA cleavage
Diego Cora, Ana Seijas, Wajih Al‐Soufi, Laura Sanchez, Álvaro J. Arana, Mercedes Novo
This study shows that Cas9 aggregation reduces in vitro DNA cleavage efficiency and highlights strategies to mitigate aggregation for better CRISPR/Cas9 performance.
International Journal of Biological Macromolecules · May 9, 2026Peer-reviewedBiochemistry