Hsc70 Ameliorates the Vesicle Recycling Defects Caused by Excess -Synuclein at Synapses
Susan M. L. Banks, Audrey T. Medeiros, Molly McQuillan, David J. Busch, Ana Sofia Ibarraran-Viniegra, Subhojit Roy, Rui Sousa, Eileen M. Lafer, Jennifer R. Morgan
This paper shows that excess α-synuclein impairs synaptic vesicle recycling by sequestering Hsc70, and that increasing Hsc70 levels can reverse this defect in a vertebrate synapse.
eNeuro · Jan 1, 2020Peer-reviewedNeuroscience