Novel Synthetic Promoter Armed Oncolytic Herpes Simplex Virus For Treatment of PAX3-FOXO1 Positive Rhabdomyosarcoma
Cole W. Peters, Miriam Valenzuela-Cardenas, Conner K. Kidd, Analynn Lechien, Andrew Dinh, Moe Kawakami, Joshua Nguyen, Allison Flores, Stephen Ma, Lance Heady, Giorgia del Vecchio, Matteo A. Pellegrini, Theodore Scott Nowicki
This paper develops a PAX3-FOXO1-targeted oncolytic herpes virus that improves tumor control in immunocompetent mouse models when combined with anti-PD1 therapy.
bioRxiv · Jun 12, 2026 · PreprintCancer Biology