Spike protein mutational landscape in India: Could Mullers ratchet be a future game-changer for COVID-19?
Rachana Banerjee, Kausik Basak, Anamika Ghosh, Vyshakh Rajachandran, Kamakshi Sureka, Debabani Ganguly, Sujay Chattopadhyay
The paper analyzes SARS-CoV-2 spike protein mutations in India, finding lower stability of spike-receptor complexes in recent variants, which correlates with declining fatality rates and suggests potential mutational meltdown.
Infection Genetics and Evolution · Apr 24, 2021Peer-reviewedBioinformatics