Proteostasis perturbation destabilizes respiratory complex assembly-intermediates via aggregation of subunits
Shivali Rawat, Anusha Valpadashi, Manoranjan Jha, K. Sreedurgalakshmi, Anamika Ghosh, Debabani Ganguly, Swasti Raychaudhuri
The paper shows that proteostasis disruption leads to RCC subunit aggregation, impairing complex assembly and causing mitochondrial dysfunction.
bioRxiv · May 2, 2018 · PreprintMolecular Biology