A TLS11a-decorated ionizable lipid nanoparticle platform and a multilevel-validated CRISPR LDLR-knockout HepG2 model for hepatocyte-preferential mRNA delivery
Irfan Hussain, Naji Kholaif, Raghad Alsultan, Rahma Eltahir, Huda Alajlan, Tanveer Ahmad Mir, Jahan Salma, Fawad Ur Rehman, Anas Mohammed Alazami, Farhatullah Syed
The paper develops an LDLR-independent LNP platform for hepatocyte-targeted mRNA delivery and validates an LDLR-knockout HepG2 model for studying LDLR biology.
bioRxiv · Jul 22, 2026 · PreprintBioengineering