DNMT3A-NPM1 mutated acute myeloid leukaemia shows sensitivity to a PARP1 inhibitor combined with daunorubicin in an in vitro model
Grigore Gafencu, Valentina Pileczki, Ancuta Jurj, Lorand Magdo, Cristina Selicean, Roxana Ola, Gabriel Ghiaur, Ioana Berindan-Neagoe, Ciprian Tomuleasa
The paper tests if PARP inhibitors combined with anthracyclines are effective against DNMT3A-NPM1 mutated AML in vitro, finding similar sensitivity to MLL-AF9 mutated leukaemias.
bioRxiv · Jul 5, 2018 · PreprintCancer Biology