A cleavable signal peptide controls the topology and Golgi targeting of the membrane protein TMEM165
Marie Odile Velings, Romain Simar, Andréa Bleret, Virginie Tevel, Marielle Boonen, Pierre Morsomme
This study identifies a cleavable signal peptide in TMEM165 essential for its Golgi targeting and membrane topology, showing that N-terminal deletions restore function and suggest the signal peptide's role in biogenesis.
bioRxiv · Aug 20, 2026 · PreprintCell Biology