Positive selection tends to act on exposed extracellular regions and delineate interaction modules targeted by pathogens
László Dobson, Éva Schád, Erzsébet Fichó, Ágnes Tantos, Andras Szabo, Gábor Tusnády, Rita Pancsa
The paper identifies positive selection in human proteins, showing PSRs are enriched in extracellular regions and interaction interfaces, and links them to pathogen targeting and drug targets.
bioRxiv · Sep 22, 2026 · PreprintMolecular Biology