László Dobson

The paper identifies positive selection in human proteins, showing PSRs are enriched in extracellular regions and interaction interfaces, and links them to pathogen targeting and drug targets.

SLiMMine predicts short linear motifs in the human proteome with high reliability, reducing false positives and discovering novel motifs.

The paper defines the binding preference of tandem SH3 domains in p47phox-related proteins and identifies potential new instances through integrative analysis and structure prediction.

The paper provides benchmark sets to evaluate AlphaFold applications without data leakage, showing the need for careful parameter optimization in disordered prediction.

The paper explores Leishmania's protein targeting systems, showing divergence from host organisms and building predictive models for protein localization and function.

This paper analyzes how AlphaFold2 has expanded structural coverage of the human transmembrane proteome compared to experimental structures alone and evaluates its effectiveness in homology searches.

LeishMANIAdb compiles experimental and predicted Leishmania secretomes and host-pathogen interactions to aid in understanding virulence mechanisms and identifying therapeutic targets.

PSINDB compiles postsynaptic protein-protein interactions with structural and biological details, providing a resource for neurobiology research.

The paper analyzes disease-causing germline mutations in coiled-coil structures and finds that N-terminal residues are critical for superhelix assembly and folding.

The paper identifies linear motifs that mediate protein trafficking to apical and basolateral membranes using machine learning models trained on human transmembrane proteins.

The paper analyzes the structural features of postsynaptic proteins to show that their combination of ordered and disordered regions enables diverse interactions crucial for learning and memory.

The paper identifies three scenarios of folding-binding interplay in IDPs, showing how binding partner properties influence protein sequence, structure, function, and regulation as much as inherent disorder.