CBF-1 promotes the establishment and maintenance of HIV latency by recruiting Polycomb repressive complexes, PRC1 and PRC2, at HIV LTR
Sonia Zicari, Kalamo Farley, Lin Sun, Liam Flinn Spurr, Andrea Dragon, Michael Bukrinsky, Gary Leonard Simon, Ashok Chauhan, Mudit Tyagi
This study shows that CBF-1 maintains HIV latency by recruiting PRC1 and PRC2 to the HIV LTR, and its knockdown or inhibition reactivates latent HIV.
bioRxiv · Aug 10, 2017 · PreprintMolecular Biology