Gary Leonard Simon

CBF-1 promotes the establishment and maintenance of HIV latency by recruiting Polycomb repressive complexes, PRC1 and PRC2, at HIV LTR

This study shows that CBF-1 maintains HIV latency by recruiting PRC1 and PRC2 to the HIV LTR, and its knockdown or inhibition reactivates latent HIV.

DNA-PK facilitates HIV transcription by regulating the activity of RNA polymerase II and the recruitment of transcription machinery at HIV LTR

This study shows DNA-PK supports HIV transcription by regulating RNA polymerase II activity and transcription machinery recruitment at HIV LTR, leading to enhanced gene expression and replication.