Mudit Tyagi

This study identifies RSK1 as a central mediator of Tau phosphorylation in response to HIV and cocaine exposure, revealing a GSK3β-independent mechanism.

This study shows that Notch3 deletion reduces HIV-1 gene expression and systemic inflammation, improving outcomes in HIV-associated chronic kidney disease.

This study identifies how cocaine activates DNA-PK, which promotes HIV transcription by relieving RNAP II pausing through TRIM28 phosphorylation.

This study shows that CBF-1 maintains HIV latency by recruiting PRC1 and PRC2 to the HIV LTR, and its knockdown or inhibition reactivates latent HIV.

This study shows DNA-PK supports HIV transcription by regulating RNA polymerase II activity and transcription machinery recruitment at HIV LTR, leading to enhanced gene expression and replication.