Distinct and Combined Interferon-α/β-receptor-1 Loss in Neurons and Astrocytes Disrupt Brain Energy Metabolism and Drive Parkinsonian Dementia
Erika B. Villanueva, Zala Zebec, Marina Cisquella-Serra, Jon Lundstrøm, JB Andersen, Filippa Liliendahl Qvist, Emil Winther Westi, Andrea Marín, Gisela Jimenez‐Duran, Lluís Riera‐Ponsati, Emilie Tresse, Oliver Kretz, Desirée Loreth, Tobias Goldmann, Thomas Blank, , Shohreh Issazadeh‐Navikas
This paper shows that loss of IFNAR1 in neurons and astrocytes disrupts brain energy metabolism and leads to Parkinsonian dementia-like features in mice.
Journal of Biomedical Science · Jun 1, 2026Peer-reviewedNeuroscience