Failure of in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes arises because of poor gamete fertilisation
Michael J Delves, Sara R Marques, Andrea Ruecker, Ursula Straschil, Celia Miguel-Blanco, María J López-Barragá, Joël Lelièvre, Irene Molina, Melanie Wree, Shinji L Okitsu, Elizabeth Winzeler, Fengwu Li, Joseph Vinetz, Sam Sheppard, Joana Guedes, , Jake Baum
This study investigates why P. falciparum gametocytes fail to form ookinetes in vitro, finding that poor gamete fertilization is the main barrier.
bioRxiv · Nov 10, 2017 · PreprintMicrobiology