Inhibition of retrotransposition improves health and extends lifespan of SIRT6 knockout mice
Matthew Simon, Michael Van Meter, Julia Ablaeva, Zhonghe Ke, Raul S. Gonzalez, Taketo Taguchi, Marco De Cecco, Katerina I. Leonova, Valeria Kogan, Stephen L. Helfand, Nicola Neretti, Asael Roichman, Haim Y. Cohen, Marina Antoch, Andrei Gudkov, , Vera Gorbunova
This study shows that inhibiting L1 retrotransposition with NRTIs improves health and extends the lifespan of SIRT6 knockout mice by reducing type I interferon response and DNA damage.
bioRxiv · Nov 4, 2018 · PreprintMolecular Biology