Increased immunogen valency improves the maturation of vaccine-elicited HIV-1 VRC01-class antibodies
Parul Agrawal, Arineh Khechaduri, Kelsey R. Salladay, Anna J. MacCamy, Duncan Ralph, Andrew O. Riker, Andrew B. Stuart, Latha Kallur Siddaramaiah, Xiaoying Shen, Frederick A. Matsen IV, David C. Montefiori, Leonidas Stamatatos
This study shows that higher valency immunogens promote the maturation of VRC01-class antibodies with broader neutralizing activity in animals.
bioRxiv · Mar 13, 2025 · PreprintImmunology