Structural Basis for Activation of HRI by the DELE1 C-terminal domain
Olawale G. Raimi, Rupam Bhattacharjee, Min Cao, Shannon Richardson, Andrew C.H. Liu, Vanesa Vinciauskaite, Carine De Marcos Lousa, Miratul M. K. Muqit, Glenn Robert Masson
This paper shows that DELE1CTD binds to HRI's N-terminal region, displacing haem and activating HRI through competition for the haem-binding site.
bioRxiv · Sep 17, 2026 · PreprintBiochemistry