Lymphatic CD49a is a driver of meningeal immune aging and cognitive decline.
Natalie M. Frederick, Rachel A. Tinkey, Gabriel A. Tavares, Caitlyn N. Dahnke, Henry Busch, Nikhita Arun, Logan Chung, Andrew D. Buxbaum, Antoine Louveau
This study identifies CD49a as a driver of lymphatic dysfunction in aging, showing its role in immune aging and cognitive decline through genetic deletion in lymphatic endothelial cells.
bioRxiv · Aug 9, 2026 · PreprintNeuroscience