Cysteine Reactivity Profiling Illuminates Monoclonal Antibody Disulfide Bond Reduction Mechanisms in Biopharmaceutical Process Intermediates
Taku Tsukidate, Zhenshu Wang, Andrew Hsieh, Patricia Rose, Xuanwen Li
This study uses chemical proteomics to profile cysteine reactivity in mAbs, revealing disulfide bond reduction mechanisms in CHO cell production.
Journal of the American Society for Mass Spectrometry · Sep 12, 2025Peer-reviewedBioengineering