Author
Merck & Co., Inc., Rahway, NJ, USA (United States)ORCID 0000-0003-3158-3635Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Ansuman Sahoo, Taku Tsukidate, Geetanjali Pendyala…·Sri Ranganayaki Madabhushi
The paper investigates how autophagy induction reduces host cell proteins in CHO cell cultures, improving polysorbate stability and mAb productivity.
Taku Tsukidate, Zhenshu Wang, Andrew Hsieh…·Xuanwen Li
This study uses chemical proteomics to profile cysteine reactivity in mAbs, revealing disulfide bond reduction mechanisms in CHO cell production.
Taku Tsukidate, Ansuman Sahoo, Geetanjali Pendyala…·Xuanwen Li
The paper identifies PPARγ as a regulator of PSDEs in CHO cells and shows that its antagonists reduce PSDE levels and improve PS stability without affecting mAb production.
Taku Tsukidate, Anita P. Liu, Shannon Rivera…·Xuanwen Li
This study optimizes an activity-based protein profiling workflow to detect polysorbate-degradative enzymes at 10 ppb in biotherapeutic samples.
Taku Tsukidate, Alyssa Q. Stiving, Shannon Rivera…·Xuanwen Li
The paper evaluates diaPASEF for HCP analysis in biopharmaceutical processes, showing improved quantification and throughput compared to standard methods.