Xuanwen Li

This paper identifies metabolic reprogramming driven by thyroid-stimulating antibodies as a key mechanism in thyroid eye disease, showing lactate promotes adipogenesis through histone lactylation.

The paper investigates how autophagy induction reduces host cell proteins in CHO cell cultures, improving polysorbate stability and mAb productivity.

This study develops YC3, a TSHR-targeting aptamer that inhibits TSHR signaling and treats Graves' ophthalmopathy by binding to a novel allosteric site.

This study uses chemical proteomics to profile cysteine reactivity in mAbs, revealing disulfide bond reduction mechanisms in CHO cell production.

The paper identifies PPARγ as a regulator of PSDEs in CHO cells and shows that its antagonists reduce PSDE levels and improve PS stability without affecting mAb production.

This paper develops an antibody-free mass spectrometry method to assess mRNA vaccine functionality and translation fidelity using cell-free translation and LC-MS.

This study optimizes an activity-based protein profiling workflow to detect polysorbate-degradative enzymes at 10 ppb in biotherapeutic samples.

The paper evaluates diaPASEF for HCP analysis in biopharmaceutical processes, showing improved quantification and throughput compared to standard methods.

The paper investigates how maternal H3.3 contributes to paternal genome reprogramming and minor zygotic genome activation in mice.