Variants in glycine decarboxylase activate mechanisms of mitochondrial energy metabolism in the brain.
Alejandro Lopez‐Ramirez, Andrew J Worth, Ziyi Wang, Saliha Yılmaz, Sebastian Hayes, Joseph D. Farris, Md. Suhail Alam†, Prasad Kottayil Padmanabhan, Kasturi Haldar
The paper investigates how GLDC variants affect mitochondrial energy metabolism in the brain, showing reduced GLDC levels and altered metabolic pathways in mutant mice.
bioRxiv · Jul 12, 2025 · PreprintNeuroscience