Alejandro Lopez‐Ramirez

Variants in glycine decarboxylase activate mechanisms of mitochondrial energy metabolism in the brain.

The paper investigates how GLDC variants affect mitochondrial energy metabolism in the brain, showing reduced GLDC levels and altered metabolic pathways in mutant mice.

Chronic HDACi emends microglial differentiation and neurological disease in a mouse model of intellectual disability

The paper shows that a triple combination of HDAC inhibitor and excipients improves microglial function in a mouse model of Kabuki Syndrome by restoring chromatin marks and cognitive responses.

Gene therapy prevents disease and death from non-ketotic hyperglycinemia

This study demonstrates that gene therapy using rAAV9-GLDC prevents disease and death in a mouse model of non-ketotic hyperglycinemia.

Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington's Disease and Possible Therapeutic Avenues

The paper uses single-cell RNA sequencing to study Huntington's disease by analyzing medium spiny neuron development in HD iPSC models and identifies potential therapeutic molecules.

Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

The paper performs proteomic analysis of Huntington's disease patient-derived medium spiny neurons, identifying altered lipid metabolism and lipid droplet accumulation as key findings.