Pharmacology & ToxicologybioRxivPreprint
The Impact of Uremia and Intestinal Dysbiosis on Hepatic Drug Metabolism in a Rat Model of Progressive Chronic Kidney Disease
Emily D Hartjes, Yong Jin Lim, Thomas J Velenosi…·Bradley L Urquhart
This study investigates how uremia and intestinal dysbiosis affect hepatic drug metabolism in a rat CKD model, finding that CYP3A2 and CYP2C11 are downregulated before dysbiosis and correlate with uremic toxins.
DOI 10.1101/531939