Mapping cell-cell fusion at single-cell resolution
Andrea L. Gardner, Lan Zheng, Kennedy K. Howland, Andrew Saunders, Andrea Ramirez, Patrik Parker, Chisom Iloegbunam, Daylin Morgan, Tyler A. Jost, Amy Brock
The paper introduces CMDuo, a tool to map cell-cell fusion events in tumors using scRNA-seq, revealing subclonal transcriptomic hybrids and fusion-driven cell states in triple-negative breast cancer.
bioRxiv · Dec 11, 2024 · PreprintSystems Biology