Amy Brock

This study identifies galectin-1 as a marker of invasive glioblastoma subpopulations and shows its role in promoting migration and tumor recurrence.

The paper uses cell barcoding to show that hiPSC lineages have different differentiation outcomes into cardiomyocytes, highlighting lineage-dependent variability in cardiac differentiation.

This study shows that dynamic electrical stimulation improves hiPSC-CM differentiation, functionality, and transcriptomic pathway enrichment compared to static or no stimulation.

This study uses deep learning to classify transcriptomic subpopulations in breast cancer cell lines based on morphology, showing that chemotherapy-induced changes and intra-line subpopulations are identifiable.

This study shows that a ketomimetic medium increases chemoresistance and invasiveness of breast cancer cells through hypersialylation and lipid synthesis pathways.

This paper compares two hiPSC differentiation protocols for endothelial progenitors, finding significant differences in cell maturity, phenotype, and vasculogenic potential.

This study uses lineage tracing and scRNA-seq to analyze clone-specific responses to doxorubicin in triple-negative breast cancer, finding no pre-existing resistance and divergent treatment responses.

The paper introduces CMDuo, a tool to map cell-cell fusion events in tumors using scRNA-seq, revealing subclonal transcriptomic hybrids and fusion-driven cell states in triple-negative breast cancer.

The paper introduces clusterCleaver, a computational tool that identifies surface markers for isolating distinct subpopulations from heterogeneous cancer cell populations using scRNA-seq data.

The paper identifies heterogeneous drug-tolerant persisters (DTPs) as population-level states with distinct division and death rates, showing increased ferroptosis susceptibility.

This study uses snRNA-seq to analyze transcriptomes of 16,000 nuclei from human prefrontal cortex in alcoholics and controls, identifying cell type-specific gene expression changes associated with alcohol dependence.

This paper introduces a functionalized lineage tracing tool that enables high diversity lineage tracking and lineage-specific gene expression manipulation.

This paper develops a multi-state model to analyze chemoresistance dynamics in breast cancer using experimental and mathematical modeling approaches.