Target-induced Argonaute-HNH filaments confer bacterial immunity
Anna Kanevskaya, Lidiya Lisitskaya, Andrey V. Moiseenko, Olga S. Sokolova, Nikolai N. Sluchanko, Andrey Kulbachinskiy
The paper shows that short prokaryotic Argonautes (pAgos) activate HNH nuclease effectors after RNA-guided DNA recognition, forming filaments that degrade DNA and confer bacterial immunity.
bioRxiv · Apr 6, 2025 · PreprintMolecular Biology