A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress
Jitendra Singh Kanshana, Polly E. Mattila, Michael Ewing, Ashlee N. Wood, Gabriele Schoiswohl, Anna C. Meyer, Aneta Kowalski, Samantha L. Rosenthal, Sébastien Gingras, Brett A. Kaufman, Ray Lu, Daniel E. Weeks, Stephen T. McGarvey, Ryan L. Minster, Nicola L. Hawley, Erin E. Kershaw
This study generates a murine model of the human CREBRFR457Q obesity-risk variant and finds it does not affect energy or glucose homeostasis under various nutritional stress conditions.
PLoS ONE · Sep 14, 2021Peer-reviewedGenetics