RUNX1T1-HDAC Reprogramming of the HOX Code Signaling Drives a Targetable Pan-Cancer Lineage Plasticity
Yuyin Jiang, Siyuan Cheng, Catherine Yijia Zhang, Xiao Jin, Longjun Li, Ha Eun Shin, Assma Alrefai, Anfeng Luo, Yaru Xu, Isaac Yi Kim, Ping Mu
The paper identifies RUNX1T1 as a marker of lineage plasticity across cancers and shows that targeting the RUNX1T1-HDAC complex can suppress plastic cell growth.
Cancer Letters · Mar 28, 2026Peer-reviewedCancer Biology