Author

Longjun Li

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

Isaac Yi KimiD· 3 shared Ping MuiD· 3 shared Siyuan ChengiD· 3 shared Yuyin JiangiD· 3 shared Catherine Yijia Zhang· 2 shared Melanie Fraidenburg· 2 shared Xiao JiniD· 2 shared Anfeng Luo· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

Isaac Yi KimORCID

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3 papers

Recent·Most cited

RUNX1T1-HDAC Reprogramming of the HOX Code Signaling Drives a Targetable Pan-Cancer Lineage Plasticity

Yuyin Jiang, Siyuan Cheng, Catherine Yijia Zhang, Xiao Jin, Longjun Li, Ha Eun Shin, Assma Alrefai, Anfeng Luo, Yaru Xu, Isaac Yi Kim, Ping Mu

The paper identifies RUNX1T1 as a marker of lineage plasticity across cancers and shows that targeting the RUNX1T1-HDAC complex can suppress plastic cell growth.

Cancer Letters · Mar 28, 2026Peer-reviewedCancer Biology

Graded Notch Signaling Functions as a Rheostat of Lineage Plasticity and Therapy Resistance in Prostate Cancer

Yuyin Jiang, Siyuan Cheng, Catherine Yijia Zhang, Xiao Jin, Longjun Li, Melanie Fraidenburg, Choushi Wang, Isaac Yi Kim, Ping Mu

This study identifies Notch signaling as a graded rheostat regulating lineage plasticity and therapy resistance in prostate cancer, showing that intermediate Notch activity maintains stem-like progenitor states and that modulating Notch levels can restore drug sensitivity.

bioRxiv · Nov 23, 2025 · PreprintCancer Biology

Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer

Yuyin Jiang, Siyuan Cheng, Longjun Li, Melanie Fraidenburg, Isaac Yi Kim, Su Deng, Ping Mu

This study identifies Notch signaling as a driver of lineage plasticity and therapeutic resistance in enzalutamide-resistant prostate cancer and shows its inhibition reverses resistance in vitro.

bioRxiv · May 26, 2025 · PreprintCancer Biology