Coordinated immune architecture underlies durable survival in pancreatic cancer
Nabeel Merali, Sakina Amin, Shihong Wu, Carlos Valverde-Hernandez, Weijia Gao, Tarak Agrebi Moumni Chouari, Chanthirika Ragulan, Hari PS, Izhar Bagwan, N D Karanjia, Rajesh Kumar, Rajiv P. Lahiri, Tim D. Pencavel, Esther Platt, Angela T. Riga, , Adam Enver Frampton
This study identifies that organized tertiary lymphoid structures (TLSs) with coordinated B and T cell zoning are associated with durable survival in pancreatic cancer, contrasting with disorganized TLSs in short-term survivors.
bioRxiv · May 4, 2026 · PreprintCancer Biology