Sakina Amin

Coordinated immune architecture underlies durable survival in pancreatic cancer

This study identifies that organized tertiary lymphoid structures (TLSs) with coordinated B and T cell zoning are associated with durable survival in pancreatic cancer, contrasting with disorganized TLSs in short-term survivors.

Hallmarks of adaptive immunity in a metastatic clear cell renal cell carcinoma (ccRCC) long-term elite survivor

This study identifies clonal persistence, tertiary lymphoid structures (TLS) engagement, and coordinated B-T cell immune surveillance as hallmarks of durable tumour control in a long-term survivor of metastatic ccRCC.

SpatioEv: Spatial evolution of protein and morphological features reveals development dynamics of cells and spatial neighbourhoods

SpatioEv analyzes spatial data to reveal cell and neighborhood dynamics, identifying disease-specific spatial signatures and developmental trajectories in tissues.

A resource for extracellular vesicles from activated CD4 T cells that relay pro-inflammatory signals

This study characterizes extracellular vesicles from activated CD4 T cells and shows their pro-inflammatory effects on antigen-presenting cells, providing a resource for EV-based therapeutic development.