Anguraj Sadanandam

This study combines collagen-targeted IL-12 with doxorubicin to improve anti-tumor effects in osteosarcoma by enhancing tumor accumulation and immune activation.

This study identifies that organized tertiary lymphoid structures (TLSs) with coordinated B and T cell zoning are associated with durable survival in pancreatic cancer, contrasting with disorganized TLSs in short-term survivors.

This paper presents a single-cell RNA sequencing atlas of the adult human male breast, revealing distinct transcriptional properties and composition compared to female breast tissue.

The paper identifies a rare multipotent epithelial cell in the fallopian tube as a potential cell-of-origin for high-grade serous ovarian cancer using multi-omic profiling and organoid models.

This study identifies cKIT as a key mediator of oxidative signaling in human mammary luminal progenitor cells and links its activation to poor outcomes in basal-like breast cancers.

This study compares proteomic profiles of adolescents and young adults with soft tissue tumours to older adults, identifying age-specific molecular features and potential therapeutic targets.

polyCluster reconciles cancer subtypes from different clustering methods to identify prognostically significant subtype communities in breast and uveal melanoma datasets.

The paper classifies epithelial cancers into five heterocellular subtypes, revealing previously unrecognized heterogeneity and identifying tissue-independent properties across cancer types.

The paper introduces a tool called phenMap that integrates clustering, phenotype association, and biomarker identification to define functional cancer subtypes with biological phenotypes.