Mechanism-aware inference of response to targeted cancer therapies
Nilabja Bhattacharjee, Sreeram Chandra Murthy Peela, Abhishek Halder, Bernadette Mathew, Swarnava Samanta, Sakshi Gujral, Stuti Kumari, Smruti Panda, Ritwik Ganguly, Gaurav Ahuja, Subhajyoti De, Angshul Majumder, Debarka Sengupta
This paper introduces FORGE, a framework that jointly models drug response and gene essentiality to identify treatment groups and predict efficacy using basal gene expression.
bioRxiv · Sep 4, 2025 · PreprintCancer Biology